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This rulemaking proposes to amend the Commission's regulations to strengthen technical provisions associated with drug testing requirements and enhance other requirements necessary to provide reasonable assurance that persons who have unescorted access to NRC-licensed facilities are fit for duty.  Specifically, this rulemaking will propose to address synthetic marijuana and cathinones and semi-synthetic opiates; prescription shopping; drug cocktailing; access to state databases for prescription medications; use of a spouse's prescription; point-of-collection testing using oral fluids or urine; hair testing for pre-access authorization; expansion of for-cause testing provisions; clarification of the 50-percent random testing rate; synthetic urine and other adulteration/subversion issues; two petitions for rulemaking associated with substance abuse professionals; one petition for rulemaking associated with synthetic drug use; and other issues identified through inspector and licensee lessons learned.  Conforming changes will also be assessed to better align the part 26 requirements with similar requirements in part 55 and part 73.  This rulemaking will also include discussion of PRM-26-4, PRM-26-7, and PRM-26-8.