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By this final rule, the Drug Enforcement Administration (DEA) would finalize its regulations to clarify: (1) the criteria by which DEA-registered practitioners may electronically issue controlled substance prescriptions; and (2) the criteria by which DEA-registered pharmacies may receive and archive these electronic prescriptions. The finalized rule would contain modifications from the interim-final rule previously published. The final regulations would modify the requirements that must be met by any registrant who wishes to dispense controlled substances pursuant to electronic prescriptions, including requirements pertaining to authorized software applications. (The final rule would maintain the discretionary usage of electronic prescriptions found in the interim-final rule.)