OSHA and other U.S. agencies have been involved in a long-term project to negotiate a globally harmonized approach to defining hazards, and providing labels and safety data sheets for hazardous chemicals. The result is the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). The GHS was adopted by the United Nations, with an international goal of as many countries as possible adopting it by 2008.

OSHA incorporated the GHS into the Hazard Communication Standard (HCS) in March 2012. The result would be more specific requirements for hazard classification, as well as standardized label components and a standard approach to conveying information on safety data sheets. The adoption has the potential to address some issues regarding accuracy and comprehensibility in the U.S., which will improve employee protection and facilitate international trade.

However, the GHS is a living document and has been updated several times since OSHA’s rulemaking. OSHA's rulemaking was based on the third edition of the GHS and the UN is currently working on the sixth. So far the changes have had some minimal effect on OSHA's rulemaking but in the upcoming edition there are some additional hazard categories that OSHA should consider picking up (desensitized explosives and pyrophoric gases). In order to maintain alignment with the GHS and other countries that have adopted the GHS, OSHA is considering rulemaking to align with the most recent version of the GHS.