EPA is reviewing public comments on the proposed amendments to the new chemicals procedural regulations under the Toxic Substances Control Act (TSCA) in 40 CFR parts 720, 721, 723, and 725. These amendments are intended to align the regulatory text with the statutory amendments that were made to TSCA in 2016 that impact the TSCA new chemicals review provisions, improve the efficiency of EPA's review processes, and update the regulations based on existing policies and experience implementing the New Chemicals Program. The proposal includes amendments that would reduce the need to redo all or part of the risk assessment by improving information initially submitted in new chemicals notices, which should also help reduce the length of time that new chemicals notices are under review. EPA is also proposing several amendments to the regulations for low volume exemptions (LVEs) and low release and exposure exemptions (LoREXs), which include requiring EPA approval of an exemption notice prior to commencement of manufacture, making per- and polyfluoroalkyl substances (PFAS) categorically ineligible for these exemptions, and providing that certain persistent, bioaccumulative, toxic (PBT) chemical substances are ineligible for these exemptions, consistent with EPA's 1999 PBT policy.