On January 14, 2025, the EPA proposed to address the unreasonable risk of injury to human health presented by C.I. Pigment Violet 29 (CASRN 81-33-4, also known as PV29), under its conditions of use as documented in EPA's January 2021 Risk Evaluation for PV29 and the September 2022 Revised Risk Determination for PV29 prepared under the Toxic Substances Control Act (TSCA). PV29 is a perylene pigment that is reddish-purple in color and is currently manufactured as a powder, slurry, or paste. It is used to dye products, such as plastics and paints, and is commonly used in automobile paints and coatings. TSCA requires that EPA address by rule any unreasonable risk of injury to health or the environment identified in a TSCA risk evaluation and apply requirements to the extent necessary so the chemical no longer presents unreasonable risk. EPA determined that dry powder PV29, but not PV29 already incorporated into a liquid mixture such as wet paint or ink, presents an unreasonable risk of injury to health due to the significant adverse health effects associated with inhalation exposure.  To address the identified unreasonable risk, EPA proposed to require the use of assigned protection factor (APF) 50 respirators and equipment and area cleaning to address the risk from inhalation exposure to dry powder PV29 (also referred to as regulated PV29), for certain conditions of use where dry powder PV29 is expected to be present to protect workers from the unreasonable risk of PV29 during manufacturing and processing, certain industrial and commercial uses of the chemical, and disposal. EPA also proposed to establish recordkeeping and downstream notification requirements. EPA's final risk evaluation for PV29, describing PV29's conditions of use and presenting EPA's determination of unreasonable risk, is in docket EPA-HQ-OPPT-2018-0604, with revised risk determination and additional information in docket EPA-HQ-OPPT-2016-0725.