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On July 22, 2016, the Comprehensive Addiction and Recovery Act of 2016 became law. One section of the CARA amended the Controlled Substances Act to expand the categories of practitioners who may, under certain conditions on a temporary basis, dispense a narcotic drug in schedule III, IV, or V for the purpose of maintenance treatment or detoxification treatment. Separately, the Department of Health and Human Services, by final rule effective August 8, 2016, increased to 275 the maximum number of patients that a practitioner may treat for opioid use disorder without being separately registered under the CSA for that purpose. By this rulemaking, DEA is amending its regulations to incorporate these statutory and regulatory changes.