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EPA issued regulations in 1989 for the "Protection in the Workplace" (40 CFR 721.63) and "Hazard Communication Program" (40 CFR 721.72) components of the Significant New Uses of Chemical Substances regulations at 40 CFR 721. Where possible, these regulations are closely aligned with Occupational Safety and Health Administration (OSHA) regulations at 29 CFR 1910.1200. OSHA issued a final rule on March 26, 2012 that aligns OSHA's Hazard Communication Standards with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). On July 28, 2016, EPA issued a proposed rule on proposing changes to the applicable Significant New Uses of Chemical Substances regulations at 40 CFR 721 to align the EPA regulations, where possible, with the final revisions to the OSHA Hazard Communications Standards (81 FR 49598).