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This proposed rule is necessary to update the regulation at 42 CFR part 68 to reflect the changes in NIH loan repayment programs (LRPs) that resulted from enactment of the 21st Century Cures Act. More specifically, the proposed rule would update the existing regulation for NIH LRPs to reflect: (a) The consolidation of NIH LRPs into two programs, the Intramural Loan Repayment Program (for NIH researchers) and the Extramural Loan Repayment Program (for non-NIH researchers); (b) the direct authority of the NIH Director to administer the NIH LRPs (formerly the duty of the Secretary, HHS); and (c) the increase in the annual loan repayment amount from a maximum of $35,000 to a maximum of $50,000.