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This rule would amend the Commission's regulations to strengthen technical provisions associated with drug testing requirements and enhance other requirements necessary to provide reasonable assurance that persons who have unescorted access to Nuclear Regulatory Commission-licensed facilities are fit for duty.  Furthermore, amendments will be proposed to help prevent the need for future part 26 rulemakings when changes occur in societal or onsite drug use and U.S. Department of Health and Human Services' guidelines for drug testing.  Specifically, this rulemaking would propose to address marijuana, synthetic marijuana, cathinones, and semi-synthetic opiates (that are being proposed for testing by the U.S. Department and Health and Human Services, HHS); prescription shopping; drug cocktailing; access to state databases for prescription medications; use of a spouse's prescription; point-of-collection testing; use of oral fluids and hair as test matrices (both being proposed by HHS); expansion of for-cause testing provisions; risk-inform the 50-percent random testing rate; synthetic urine and other adulteration/subversion issues; two petitions for rulemaking associated with substance abuse professionals; one PRM associated with synthetic drug use; and other issues identified through inspector and licensee lessons learned. Conforming changes would also be assessed to better align the part 26 requirements with similar requirements in part 55 and part 73.  This rulemaking would also include discussion of PRM-26-4, PRM-26-7, and PRM-26-8.