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EPA proposed a significant new use rule (SNUR) under section 5(a)(2) of the Toxic Substances Control Act (TSCA) for 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, and toluene diisocyanate unspecified isomers (these three chemical substances are hereafter referred to as toluene diisocyanates or TDI) and related compounds. On January 15, 2015, EPA proposed to designate as a significant new use any use of TDI and related compounds in a consumer product, with a proposed exception: use of certain chemical substances in coatings, elastomers, adhesives, binders, and sealants that results in less than or equal to 0.1 percent by weight of TDI in a consumer product. In addition, EPA proposed to make inapplicable the general SNUR exemption from notification for persons who import or process these chemical substances as part of an article. Persons subject to the SNUR would be required to notify EPA at least 90 days before commencing any manufacturing (including importing) or processing. The required notification would initiate EPA's evaluation of the intended use within the applicable review period. Manufacture and processing for the significant new use would be unable to commence until EPA has conducted a review of the notice, made an appropriate determination on the notice, and taken such actions as are required in association with that determination. EPA is now finalizing this SNUR for TDI and related compounds. There are no changes in the chemicals subject to the SNUR between the proposed and final rule.