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This action proposes to establish the scientific and technical guidelines for the inclusion of urine specimens in the Mandatory Guidelines for Federal Workplace Drug Testing Programs and standards for certification of laboratories engaged in drug testing for federal agencies. This final rule would adopt a more efficient method of updating the drug testing panel for the federal workplace drug testing programs. Additional changes subject to public comment include further revisions to the Section 3.4 drug testing panel and revisions to align the HMG with the final Mandatory Guidelines for Federal Workplace Drug Testing Programs using Urine (UrMG) and the final Mandatory Guidelines for Federal Workplace Drug Testing Programs using Oral Fluid (OFMG), both published in the April 7, 2022 Federal Register (87 FR 20560 and 87 FR 20522,respectively).