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DOJ/DEA RIN: 1117-AB72 Publication ID: Fall 2023 
Title: Changes to a Prescription 

The purpose of this rule is to modify 21 CFR 1306.05(a) to stipulate when pharmacists and/or pharmacist technicians can make changes and/or additions to schedule II-V written controlled substance prescriptions once a prescription has been signed by a DEA registered practitioner. Currently, 21 CFR 1306.05(a) does not state when or if any changes and/or additions can be made to a controlled substance prescription once a prescription has been signed by a DEA registered practitioner. This uncertainty can result in delays for patients receiving prescriptions of controlled substances.

In determining what regulation changes needed to occur, DEA reviewed questions, issues, and concerns that have been raised by patients, caretakers, underserved communities, medical and pharmacy professionals during various industry meetings, local outreach efforts, webinars, conferences, or via correspondence.

DEA will publish an NPRM, continue to engage with stakeholders, patients in underserved communities, and take into consideration accepted and recommended industry standards, while ensuring patient’s public health and safety, prior to the publication of the rule.


Agency: Department of Justice(DOJ)  Priority: Substantive, Nonsignificant 
RIN Status: Previously published in the Unified Agenda Agenda Stage of Rulemaking: Proposed Rule Stage 
Major: No  Unfunded Mandates: No 
CFR Citation: 21 CFR 1306   
Legal Authority: 21 U.S.C. 821, 827, 871(b)   
Legal Deadline:  None
Action Date FR Cite
NPRM  12/00/2023 
Additional Information: DEA Docket number 761
Regulatory Flexibility Analysis Required: No  Government Levels Affected: None 
Small Entities Affected: Businesses  Federalism: No 
Included in the Regulatory Plan: No 
RIN Information URL:   Public Comment URL:  
RIN Data Printed in the FR: No 
Agency Contact:
Scott A. Brinks
Section Chief, Regulatory Drafting and Support Section, Diversion Control Division
Department of Justice
Drug Enforcement Administration
8701 Morrissette Drive,
Springfield, VA 22152
Phone:571 362-8209